Printing History was founded in 1979; since then it has been edited by Susan Otis Thompson, Anna Lou Ashby, Renee I. Weber, and David Pankow. The first 50 issues of the journal constitute the Original Series—many of which are now on sale.

Printing History New Series began in 2007 under the editorship of William S. Peterson, Professor Emeritus of English at the University of Maryland, former editor of Papers of the Bibliographical Society of America, and the author of books about the Kelmscott Press and Daniel Berkeley Updike.

In July 2011, Peterson was succeeded by William T. La Moy, curator of rare books and printed materials at the Special Collections Research Center at Syracuse University Library.  

In 2016,  La Moy was succeeded by Brooke S. Palmieri, a Ph.D Candidate in History at University College London.

In 2021, George Barnum, then Vice President for Publications, edited NS 29/30

In 2022, Daniel Arbino was the guest editor for NS 31/32. 

In 2023, Danelle Moon was the guest editor for NS 33. 

In 2024, Josef Beery was the guest editor for NS 34.  Aaron Pratt and Brittney Washington were guest editors for NS 35

In 2045, Sam Regal became editor starting with NS 36.